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High-Phenolic EVOO can improve the prognosis for some Leukemia Patients, Clinical Trial

Updated: Apr 3, 2022

New research resulting from a small but significant clinical trial in Greece finds that consuming High-Phenolic Extra Virgin Olive Oil may help to slow, and in some cases even reverse the progression of one of the most common types of Cancers - Chronic Lymphocytic Leukemia (CLL).


" It was a very small number of patients, but even in that small number,

there was a statistically significant difference after three months of intervention "

-Prokopios Magiatis, Associate Professor at the University of Athens


The Clinical Trial

Researchers from the World Olive Center for Health found that consuming olive oil with high concentrations of Oleocanthal and Oleacein improved the prognosis of a sample of patients with early-stage Chronic Lymphocytic Leukemia (CLL) which makes up about 25% of global leukemia cases.

It all started with a lady that contacted Prokopios Magiatis, associate Professor at the University of Athens - Dept. Pharmacognosy, in 2015 to ask if she could consume High-Phenolic EVOO to help with her prognosis. Magiatis told her it could not hurt and six months later she called in tears, saying that it was a miracle that her white blood cell count has gone down.

Magiatis and his team saw this as a great starting point and decided to see if they could repeat the findings in a clinical trial. The study was run among patients in Greece at the early stages of the disease. The researchers divided the patients into two groups. The first group consumed 40ml/day of a High-Phenolic EVOO with 25 milligrams of Oleocanthal and Oleacein for 3 months. The second group consumed 40ml/day of oil with high polyphenols but low concentrations of Oleocanthal and Oleacein for the same period. (see the full analysis and a comparison to PhenOLIV Organic at the end of the article)

The Results

By the end of the study, researchers observed that white blood cell production had slowed down in the patients consuming high-Oleocanthal, high Oleacein olive oil, and in some cases, even reversed.


“ It not only stopped the increase [of white blood cells],

but we observed a significant reduction of white blood cells ”

-Prokopios Magiatis, Associate Professor at the University of Athens


Researchers also observed benefits in the glucose metabolism of patients, who all suffer from increased glucose levels, one of the effects of leukemia. Blood sugar levels returned to normal values after 3 and 6 months.

The team concluded that they need to run a larger trial for a longer period with only high-oleocanthal and high-oleacein olive oil and are already working on such a trial that will follow at least 100 patients for a year (here at The Greek Olive Estate we have already offered to provide such oil)

Magiatis cautioned that these studies would take years to complete. In the meantime he sees these preliminary results as solid evidence that the consumption of EVOO high in Oleocanthal and Oleacein is a low-risk intervention for chronic lymphocytic leukemia patients. In any case, Magiatis stressed that there was nothing to lose.


"...the addition of olive oil in the diet of any patient is something

that does not create any risk to their health, they can only get benefits"

-Prokopios Magiatis, Associate Professor at the University of Athens


Where to Buy

Our High-Phenolic Extra Virgin Olive Oil PhenOLIV Organic has even higher Oleocanthal and Oleacein levels (783 mg/kg) than the high OC/OL-EVOO used in the clinical trial (700 mg/kg). Worth noting that not all High-Phenolic EVOOs are the same, even the LOW OC/OL-EVOO used in the trial contained 505mg/kg total polyphenols, but only 115mg/kg Oleacanthal and Oleacein.


Low OC/OL-EVOO used in Trial:

Oleocanthal 82 ± 5 mg/kg, oleacein 33 ± 3 mg/kg,

tyrosol 250 ± 10 mg/kg, hydroxytyrosol 140 ± 9 mg/kg

(Oleocanthal + Oleacein (D1) = 115 mg/kg, Total Phenolic Content = 505 mg/kg)

High OC/OL-EVOO used in Trial:

Oleocanthal 416 ± 7 mg/kg, Oleacein 284 ± 10 mg/kg,

oleuropein aglycon monoaldehyde 41 ± 3 mg/kg, ligstroside aglycon monoaldehyde 34 ± 3 mg/kg, oleokoronal 78 ± 4 mg/Kg, oleomissional 33 ± 3 mg/kg,

tyrosol <10 mg/kg, hydroxytyrosol <10 mg/kg

(Oleocanthal + Oleacein (D1) = 700 mg/kg, Total Phenolic Content = 886 mg/kg).

PhenOLIV Organic - October 2021 Harvest:

Oleocanthal 479 mg/kg, Oleacein 303 mg/kg,

oleuropein aglycon monoaldehyde 309 mg/kg, ligstroside aglycon monoaldehyde 263 mg/kg, oleokoronal 160 mg/Kg, oleomissional 609 mg/kg,

tyrosol <10 mg/kg, hydroxytyrosol <10 mg/kg

(Oleocanthal + Oleacein (D1) = 783 mg/kg, Total Phenolic Content = 2124 mg/kg)


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