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How The Olive Compound Hydroxytyrosol Helps Stop Infections

A compound found naturally in olives helps fight bacterial infections, according to an international patent application by Spanish scientists.

They say hydroxytyrosol and derivatives of it can disrupt quorum sensing (QS) – a way in which bacteria ‘talk’ to each other – thereby making infections less virulent. With antibiotic resistance increasing, this is seen as a promising way of treatment.

Madrid-based patent applicant Seprox Biotech, which sells hydroxytyrosol (HT), claims that HT and its derivatives hydroxytyrosol acetate (HTA) and 3,4-dihydroxyphenylacetic acid (DOPAC) have good anti-QS activity, making them useful for preventing and treating many kinds of infections.

Potential usage

It said in its application that in vivo uses could include pharmaceutical preparations for the treatment of bacterial infection. Ex vivo uses include in the manufacture of food, food packaging, medical devices and pharmaceutical compositions, including application to or use in the making of surfaces – such as in medical devices and foods or food packaging – to inhibit formation of bacterial biofilm.

Biofilm formation – where microorganisms latch onto a surface – is a big issue amid increasing use of implants, artificial heart valves and so on, but can be extremely resistant to removal and disinfection, it said.

Source: Olive Oil Times