Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial
Highlights EVOO varietal differences influence platelet aggregation and oxylipinproduction. Inhibition of platelet aggregation correlated to oleocanthal content. Inhibition of eicosanoids correlated to EVOO total phenolic content. Basal diet may influence... Read More
(−)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma
Abstract We explored the anti-cancer capacity of (−)-oleocanthal in human hepatocellular carcinoma (HCC). (−)-Oleocanthal inhibited proliferation and cell cycle progression and induced apoptosis in HCC... Read More
Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model
Abstract Numerous clinical and preclinical studies have suggested several health promoting effects for the dietary consumption of extra-virgin olive oil (EVOO) that could protect and... Read More
(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization.
Abstract (-)-Oleocanthal (OC), a phenolic compound present in extra-virgin olive oil (EVOO), has been implicated in the health benefits associated with diets rich in EVOO.... Read More
Olive-Oil-Derived Oleocanthal Enhances β‑Amyloid Clearance as aPotential Neuroprotective Mechanism against Alzheimer’s Disease:In Vitro and in Vivo Studies
Oleocanthal, a phenolic component of extravirgin olive oil, has been recently linked to reduced risk of Alzheimer’s disease (AD), a neurodegenerative disease that is characterized by accumulation... Read More
Modulation of tau protein fibrillization by oleocanthal.
Among the phenolic compounds extracted from extra virgin olive oil, oleocanthal (1) has attracted considerable attention in the modulation of many human diseases, such as... Read More
(-)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers.
Abstract The proto-oncogene receptor tyrosine kinase c-Met encodes the high-affinity receptor for hepatocyte growth factor (HGF). Dysregulation of the HGF-c-Met pathway plays a significant oncogenic... Read More
Alzheimer’s-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal
It now appears likely that soluble oligomers of amyloid-β1-42 peptide, rather than insoluble fibrils, act as the primary neurotoxin in Alzheimer’s disease (AD). Consequently, compounds capable... Read More
Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau
Abstract Tau is a microtubule-associated protein that promotes microtubule assembly and stability. In Alzheimer’s disease and related tauopathies, tau fibrillizes and aggregates into neurofibrillary tangles.... Read More
Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.
Abstract Newly pressed extra-virgin olive oil contains oleocanthal–a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions... Read More